|
KMID : 0379520220380040437
|
|
한국독성학회지
2022 Volume.38 No. 4 p.437 ~ p.447
|
|
|
Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice
|
|
Kumar Arun
Kumar Vikas
Akhouri Vivek
Kumar Ranjit
Ali Mohammad
Rashmi Tuhin
Chand Gyanendra Bahadur
Singh Sushil Kumar
Ghosh Ashok Kumar
|
|
|
Abstract
|
|
|
|
Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic exposure through drinking water to humans leads to major public health related issues. There have been very meagre studies which reported that, the plant constituents proved to exhibit protective effect from arsenicosis. Therefore, the present study aims to evaluate the protective efficacy of Coriandrum sativum seeds extract against sodium arsenite induced toxicity in Swiss albino mice. In the present study twenty-four male healthy Swiss albino mice (30?±?5 g) were divided into four groups (n?=?6), where the control group received normal diet and water; group II and group III treated with sodium arsenite (2 mg per kg body weight per day) for 2 and 4 weeks respectively. The group IV mice were administered with C.sativum seeds extract at the dose of 150 mg per kg body weight per day for 4 weeks upon sodium arsenite pretreated (2 mg/kg body weight for 4 weeks per day) mice. After the complete dose duration, all the treatment group animals were sacrificed same day for haematological, biochemical and histopathological study. In the arsenic treated mice, there were significant (p?
|
|
|
KEYWORD
|
|
|
Sodium arsenite, Coriandrum sativum seeds, Hepato-renal protection, Swiss albino mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|